GLUTATHIONE REDUCTASE IN RED BLOOD-CELLS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 8  (1) , 23-29
Abstract
Glutathione reductase plays an important role in protecting Hb, red cell [human] enzymes, and biological cell membranes against oxidative damage by increasing the level of reduced glutathione (GSSGR) in the process of aerobic glycolysis. The enzyme deficiency may result in mild to moderately severe hemolytic anemia upon exposure to certain drugs or chemicals. Hereditary deficiency of the enzyme is extremely rare. Recent studies on glutathione reductase in the red cell showed more insight in the understanding of red cell metabolism and interactions with other enzymes, especially glucose-6-phosphate dehydrogenase (G-6-PD). Glutathione reductase in serum may be a source of error in any clinical laboratory test in which an enzyme activity is determined indirectly by measuring the change in NADH or NADPH absorbance. Glutathione reductase levels are reduced in banked blood when citrate-phosphate-dextrose (CPD) is used as a preservative. Reviewed is the role of glutathione reductase in the metabolism of the red cell and its clinical implication and usefulness.

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