Methylation of the α2(I) collagen gene in chemically transformed rat liver epithelial cells
- 1 July 1988
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 253 (1) , 269-273
- https://doi.org/10.1042/bj2530269
Abstract
W8 cells, 2-N-(acetyoxyacetyl)aminofluorene-transformed rat liver epithelial-like cells, secrete no .alpha.2(I) collagen chains. This paper reports the first demonstration of DNA methylation in the promoter-5'' region of an .alpha.2(I) collagen gene which occurs in W8 cells. Since inhibition of methylation by azacttidine induces transcription of the .alpha.2(I) gene, DNA methylation of W8 .alpha.2(I) promoter-5'' region could contribute to altered collagen production in these cells.This publication has 29 references indexed in Scilit:
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