Induction of the Interferon System by Various Inducers

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Abstract
Studies of the comparative induction of interference by virus, statolon, and interferon in mouse embryo (ME) and African green monkey kidney (AGMK) cell cultures were performed. The major portion of the interference induced by different viruses in AGMK was characterized as being interferonlike. In both cell systems resistance was observed to develop before appearance of detectable interferon. Decline of resistance after removal from ME cells of unadsorbed statolon and NDV was slower than after removal of interferon. Possible significances of these observations are considered.