Cerebroside Antibody Inhibits Sulfatide Synthesis and Myelination and Demyelinates in Cord Tissue Cultures
- 8 February 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4124) , 540-542
- https://doi.org/10.1126/science.183.4124.540
Abstract
Antiserum to cerebroside was prepared in rabbits by injection of cerebroside together with bovine serum albumin in complete Freund's adjuvant. When applied to cultures of embryo mouse spinal cord at explantation, this antiserum inhibited sulfatide synthesis and myelination; when applied to myelinated cultures it inhibited sulfatide synthesis and produced demyelination. Complement fixation assays also show antibody to cerebroside in serums from rabbits with experimental allergic encephalomyelitis induced by injection of whole white matter. Absorption of such serum with cerebroside abolishes the inhibiting and demyelinating activities.Keywords
This publication has 14 references indexed in Scilit:
- Myelination Inhibition Factor: Dissociation from Induction of Experimental Allergic EncephalomyelitisScience, 1973
- Sulfatide Synthesis: Inhibition by Experimental Allergic Encephalomyelitis SerumScience, 1972
- EXPERIMENTAL ALLERGIC ENCEPHALOMYELITISJournal of Neuropathology and Experimental Neurology, 1970
- The in vitro demyelinating activity of sera from guinea pigs sensitized with whole CNS and with purified encephalitogenExperimental Neurology, 1968
- IMMUNOCHEMICAL AND SEROLOGICAL STUDIES ON THE LIPID HAPTEN OF MYELIN WITH RELATIONSHIP TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS (EAE)Annals of the New York Academy of Sciences, 1965
- THE APPLICATION OF TISSUE CULTURE TO THE STUDY OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITISThe Journal of Experimental Medicine, 1964
- Immunochemische Untersuchungen zur Identifizierung eines äthanollöslichen MyelinhaptensJournal of Molecular Medicine, 1963
- Identification of an Organ Specific Lipid Hapten in BrainNature, 1963
- The Application of Tissue Culture to the Study of Experimental “Allergic” Encephalomyelitis*Journal of Neuropathology and Experimental Neurology, 1961
- THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAINThe Journal of Experimental Medicine, 1934