MONOCLONAL-ANTIBODIES TO ALZHEIMER NEUROFIBRILLARY TANGLES .2. DEMONSTRATION OF A COMMON ANTIGENIC DETERMINANT BETWEEN ANT AND NEUROFIBRILLARY DEGENERATION IN PROGRESSIVE SUPRANUCLEAR PALSY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 120  (2) , 292-303
Abstract
Neurofibrillary degeneration is an argyrophilic intraneuronal lesion found in several unrelated neurologic conditions. The relationship between different types of neurofibrillary tangles is investigated with 2 monoclonal antibodies raised against Alzheimer neurofibrillary tangles (anti-ANT). Using the peroxidase-antiperoxidase technique, neurofibrillary tangles of progressive supranuclear palsy, containing 15-nm straight filaments, were shown to share an antigenic determinant with ANTs. Ultrastructural studies localize the antigenic determinant to filamentous elements in the parakarya. The determinant is not present in normal brain, Al-induced experimental tangles in the rabbit, Lewy bodies, Hirano bodies, or axonal filamentous inclusions of amyotrophic lateral sclerosis and giant axonal neuropathy. It is, present in ANTs regardless of the pathologic condition in which they are found, including Alzheimer''s disease, Down''s syndrome, and postencephalitic Parkinson''s disease.