Out, Damned CLIP! Out, I Say!
- 25 October 1996
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 274 (5287) , 526-527
- https://doi.org/10.1126/science.274.5287.526
Abstract
The major histocompatibility complex (MHC) class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the class II binding groove, a place-holding peptide CLIP must be removed. This is accomplished by the molecule DM, which is shown to increase the dissociation rate of a small class II-associated Ii peptide (CLIP) from class II (see report by Weber et al ., p. 618 ). Roche explains how DM can tell the difference between the class II-CLIP and foreign peptide-CLIP complexes.This publication has 6 references indexed in Scilit:
- Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DMScience, 1996
- The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3Nature, 1995
- ArticleImmunity, 1995
- HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loadingCell, 1995
- An essential role for HLA–DM in antigen presentation by class II major histocompatibility moleculesNature, 1994
- Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing MutantScience, 1992