Enhanced production of dolichol, but not dolichyl phosphate, in the earliest stages of rat liver regeneration
- 1 April 1986
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 6 (4) , 409-413
- https://doi.org/10.1007/bf01116429
Abstract
The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable. The greater amount ofmevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence.This publication has 24 references indexed in Scilit:
- Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regenerationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- The modulating effect of an inhibitor of cholesterolgenesis present in bovine milk upon the synthesis of cholesterol, dolichol and ubiquinoneAtherosclerosis, 1983
- Control and manipulation of the phosphodolichol pathway of proteinN-glycosylationBioscience Reports, 1982
- Biosynthesis of dolichol and cholesterol during embryonic development of the chickenBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
- Evidence for the stimulation of dolichol and mannolipid synthesis by glucocorticoids in HeLa cellsBiochemical Journal, 1981
- Regulation of dolichol and of cholesterol biosynthesis in cholesterol-fed rabbitsArchives of Biochemistry and Biophysics, 1981
- Increased hepatic dolichol and dolichyl phosphate-mediated glycosylation in rats fed cholesterolArchives of Biochemistry and Biophysics, 1981
- Isopentenyladenine as a mediator of mevalonate-regulated DNA replication.Proceedings of the National Academy of Sciences, 1980
- Essential role for mevalonate synthesis in DNA replicationProceedings of the National Academy of Sciences, 1979