Myocardial fascicle and fiber disarray in 25 mu-thick sections.

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Abstract
The histology of myocardial fiber disarrays was compared in thin (4 .mu.) and thick (25 .mu.) sections of tissues obtained at autopsy from 18 adults and 8 infants with clinically normal hearts, from 10 hearts with concentric hypertrophy (hypertensive patients), 9 with myocardial infarction and 4 with hypertrophic cardiomyopathy (HCM). In the thick sections, so-called bizarre myocardial fiber disarray in thin sections appeared as a bizarre fascicle disarray. The usual disarray in cases of HCM is actually a fascicle disarray with a 3-dimensional complex network. There was no marked difference in distribution and frequency of fascicle disarray between normal adult and infant hearts, and diseased hearts with hypertension and myocardial infarction. In the 4 hearts with HCM, diffuse bizarre fascicle disarray in the thick section was detected in the septum and anterior and posterior walls of the left ventricles in all cases, and in the lateral walls in 1 case. In the portions without the diffuse fascicle disarray, the distribution of disarray was the same as that in hearts with no HCM. Such fascicle disarray, including that of HCM, is probably congenital.