Distribution and degranulation of airway mast cells in normal and asthmatic subjects
- 1 May 2002
- journal article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 19 (5) , 879-885
- https://doi.org/10.1183/09031936.02.00275802
Abstract
It was hypothesized that the distribution and activation of mast cells across the airway wall may reflect their function in asthma.The density of mast cells (intact and degranulated) within airway compartments in cartilaginous and membranous airways, obtained from autopsies on patients with fatal asthma, nonfatal asthma, and nonasthmatic control cases have been examined.In cartilaginous airways, the mean±se density of mast cells in control cases was 27±9 cells·mm−2. It was similar in nonfatal asthma (24±2 cells·mm−2) but reduced (p−2). In membranous airways, the density of mast cells in control cases was 155±21 cells·mm−2and was higher (p−2) and fatal asthma (219±26 cells·mm−2). Mast-cell density was greatest on the smooth muscle and mucous glands in cartilaginous airways and on the smooth muscle and outer airway wall in membranous airways. The percentage of degranulated mast cells was higher (pviathe inhaled route.Keywords
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