The Effect of Urethane on Lymphatic Leukemia in Rats

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Abstract
Fifty rats were inoculated with a transplanted disease which manifests itself as a generalized lymphatic leukemia if the malignant cells are inj. intraperitoneally or as a localized lymphosarcoma when the cells are inoculated into the subcut. tissue of the groin. The treated rats were given from 50-100 mg. of urethane/100 g. body wt., 4 times a wk., and only 3 of 50 rats developed leukemia. Among 41 controls without urethane treatment, 33 developed fatal leukemia. Among 30 rats inoculated in the groin with leukemia cells and given urethane, only 9 developed progressive tumors, whereas 26 of 30 controls died of lymphosarcoma. The adrenals of rats given urethane showed about 33% increase in wt. over those of normal, untreated animals.

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