EXPERIMENTAL STUDIES WITH PRESTONAL, A NEW SHORT-ACTING MUSCLE RELAXANT

Open Access
Publisher Website
Google Scholar
Abstract
The effects of Prestonal on the tidal volume of 51 patients were investigated.The duration of action of Prestonal was found to be between those of suxamethonium and decamethonium. 0.75 mg/kg Prestonal caused apnoea lasting about 3 minutes in most subjects. The duration of respiratory depression after this dose was about 7 minutes. 1.5 mg/kg Prestonal caused apnoea of 5 minutes and respiratory depression of about 12 minutes duration.Prestonal was found to have relatively little cumulative effect.A transient fall of blood pressure and flushing of the skin were occasionally seen following intravenous administration of 1.5 mg/kg Prestonal.The respiratory effects of Prestonal were markedly potentiated by the subsequent intravenous administration of 0.3 mg/kg edropho-nium. The potentiating effects of neostigmine and pyridostigmine were less marked.The effect of edrophonium, pyridostigmine and neostigmine on the myoneural effects of Prestonal indicated that this compound produced a depolarization block in man.

This publication has 0 references indexed in Scilit: