Cyclizine Toxicity — Intentional Drug Abuse of a Proprietary Antihistamine

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Abstract
THE list of seemingly "harmless" drugs that can produce toxic reactions is growing, largely because of misuse by youths in search of "kicks." Three boys who took massive overdoses of a supposedly nontoxic proprietary antihistamine provide the basis for this short report. Their signs and symptoms were similar to those recently described in cases of diphenhydramine1 and stramonium2 , 3 poisoning.Case ReportsAt 7:30 p.m. each of 3 17-year-old preparatory-school juniors voluntarily ingested 15 tablets (750 mg) of cyclizine† to experience a "high." They had obtained the drug upon request at a local pharmacy. Within half an hour, they became euphoric . . .

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