Absorption of Cholesteryl Methyl Ether and Its Effect on Cholesterol Absorption

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Abstract
Oral administration of the methyl ether of cholesterol-4-C14 to lymph duct cannulated rats resulted in approximately 20% recovery of C14 activity in a 24-hr, lymph collection as compared to 35% recovery in the case of cholesterol-4-Cl4. The methyl ether of cholesterol-4-C14 was recovered unchanged whereas the administered free cholesterol-4-C14 was recovered primarily in the esterified form. Simultaneous administration of cholesteryl methyl ether with cholesterol-4-C14 had no effect on cholesterol-4-14 absorption in the cannulated rat. In the rabbit, dietary cholesteryl methyl ether had negligible effect on sterol levels when given alone or in conjunction with cholesterol.