REVERSAL BY GLUCOCORTICOID HORMONES OF THE LOSS OF A FIBRONECTIN AND PROCOLLAGEN MATRIX AROUND TRANSFORMED HUMAN-CELLS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (6) , 2077-2083
Abstract
Confluent cultured human skin fibroblasts had an extracellular fibrillar matrix of fibronectin and procollagen. Human skin fibroblasts transformed by SV40 did not have such a matrix. Treatment of transformed fibroblasts with 10-5-10-8 M dexamethasone and 10-5-10-7 M cortisol, but not testosterone or progesterone, caused partial restoration of the matrix. Glucocorticoid-treated transformed human fibroblasts can serve as a model for partial reversion toward normal or differentiation of transformed human fibroblasts.

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