Second Neoplasm — A Complication of Cancer Chemotherapy

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Abstract
Chemotherapy has become increasingly important in the treatment of neoplastic disease in the past two decades. Appreciable numbers of patients with advanced Hodgkin's disease, choriocarcinoma, acute lymphocytic leukemia, testicular carcinoma and histiocytic lymphoma have achieved long-term disease-free survival largely as the result of aggressive chemotherapy. In addition, the use of antineoplastic drugs has recently been extended to the "adjuvant" situation and appears to delay, if not to prevent, recurrence in high-risk patients after primary surgical treatment of breast cancer.1 , 2 This progress has been realized despite substantial drug-related morbidity, and occasional mortality. The acute toxicity of antineoplastic chemotherapy affects a broad . . .