Autoantibodies against the High-Affinity IgE Receptor as a Cause of Histamine Release in Chronic Urticaria
Open Access
- 3 June 1993
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (22) , 1599-1604
- https://doi.org/10.1056/nejm199306033282204
Abstract
Most urticarias are induced by vasoactive mediators such as histamine released from mast cells. Although mast cells are activated by allergens through cross-linking of cell-surface-bound IgE, this mechanism does not appear to explain most cases of chronic urticaria, which, when allergic, infectious, drug-induced, or physical causes cannot be identified, are classified as idiopathic.Keywords
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