Experimental Comparative Study on Myelotoxicity of 4′-Deoxy-4′-I-Doxorubicin and of Doxorubicin
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 34 (4) , 354-359
- https://doi.org/10.1159/000238591
Abstract
4′-Deoxy-4′-I-doxorubicin (I-Dx) is 1.5–2 times more potent than doxorubicin (Dx) on some mice tumors and does not seem to be cardiotoxic. A comparison was made of the effects of both anthracyclines on mice bone marrow hemopoietic progenitors (CFU-S, GM-CFC) and peripheral blood cells. The experimental model is based on dose survival and time survival curves following single or repeated (1 weekly administration for 4 weeks) doses. Results indicate slightly higher sensitivity of assayed populations to I-DX than to Dx.Keywords
This publication has 1 reference indexed in Scilit:
- A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow CellsRadiation Research, 1961