Effects of thiosemicarbazide on spinal reflex activity

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Abstract
Thiosemicarbazide (TSC) causes an increase in the amplitude of spinal mono- and polysynaptic reflex responses. Bulbar reticular inhibition of these reflexes is no longer demonstrable after this drug is injected. Pyridoxine reverses the above mentioned effects, leading to the conclusion that blockade of a pyridoxal -dependent enzymatic system by TSC is responsible for the electrophysiologic changes. Evidence is cited that suggests that this enzymatic system is involved in the metabolism of gamma-aminobutyric acid. It is concluded that a result of TSC administration is an increase in the level of excitability of spinal structures, quite in agreement with its powerful convulsant effects.

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