Antenatal diagnosis of trisomy 13 with unexpected increase in alpha-feto protein.
Open Access
- 1 October 1976
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 13 (5) , 400-402
- https://doi.org/10.1136/jmg.13.5.400
Abstract
A 24-year-old woman who had previously given birth to an infant with Down's syndrome was shown by chromosomal analysis of the liquor amnii to be carrying an infant with trisomy D. Routine examination of serum and liquor alpha-feto protein (AFP) in the antenatal period showed unexpected high levels of both, consistent with a neural tube defect. The fetus, however, did not have evidence of a neural tube defect but had scalp defects which were presumed to have allowed the leakage of AFP from the fetus into the liquor amnii and hance into the maternal serum.This publication has 6 references indexed in Scilit:
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- Congenital Absence of the Scalp and Skull*Annals of Surgery, 1956