Enflurane Causes a Prolonged and Reversible Increase in the Rate of CSF Production in the Dog

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Abstract
Using the open ventriculocisternal perfusion method, rates of CSF production and reabsorption by bulk flow were examined in dogs anesthetized with either enflurane (2.2%) in N2 (60-70%) and O2, or N2O (60-70%) and enflurane (< 0.2%) in O2 (controls). The mean rate of CSF production increased significantly with enflurane (2.2%) from 0.055 .+-. 0.020 ml/min (mean) in controls to 0.082 .+-. 0.033 ml/min (n = 12). After this initial increase of .apprx. 50%, the production rate decreased significantly by .apprx. 7.4%/h. When the expired concentration of enflurane was decreased from 2.2 to < 0.2%, the mean rate of CSF production decreased to control values at 45-50 min. An intracerebral accumulation of CSF resulting from this enflurane-induced increase in CSF production may contribute in part to increased intracranial pressure when the dura is intact.

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