Immunoreactivity for the β chain of the platelet‐derived growth factor receptor in malignant mesothelioma and non‐neoplastic mesothelium

Publisher Website
Google Scholar
Abstract
The results of an immunohistochemical study of platelet‐derived growth factor receptor (PDGF‐R)β chain in human non‐neoplastic mesothelium (35 cases) and in malignant mesothelioma (33 cases) using a murine monoclonal antibody are reported. In approximately half of the malignant mesotheliomas, there was immunoreactivity in the cytoplasm of the neoplastic cells for the β chain of the PDGF‐R. In some cases, there was also membrane immunoreactivity. There were no statistically significant differences between the various mesothelioma subtypes. Immunoreactivity for PDGF‐R β chain was absent in non‐neoplastic mesothelium.