Origin of the genetic code: a testable hypothesis based on tRNA structure, sequence, and kinetic proofreading.
- 1 September 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (9) , 4334-4338
- https://doi.org/10.1073/pnas.75.9.4334
Abstract
The origin of the genetic code is probably associated with the structure of the tRNA that existed in primal cells. The sequences of modern [Escherichia coli] tRNA contain correlations which can be understood as fossil evidence of the secondary structure of primal tRNA. Kinetic proofreading through diffusion can amplify a low level of intrinsic selectivity of tRNA for its amino acid. Experimental tests of the theory are suggested.This publication has 29 references indexed in Scilit:
- Evolution of the genetic apparatusPublished by Elsevier ,2004
- The rates of evolution in some ribosomal componentsJournal of Molecular Evolution, 1977
- Possibilities for the Evolution of the Genetic Code from a Preceding FormNature, 1973
- Studies on 5 s RNA conformation by partial ribonuclease hydrolysisJournal of Molecular Biology, 1971
- Molecular Mechanics of Translation : a Reciprocating Ratchet MechanismNature, 1970
- Models for the evolution of codon assignmentsJournal of Molecular Biology, 1969
- The origin of the genetic codeJournal of Molecular Biology, 1968
- A speculation on the origin of the genetic codeJournal of Theoretical Biology, 1967
- Triplet Nucleotide–Amino-acid Pairing; a Stereo-chemical Basis for the Division between Protein and Non-protein Amino-acidsNature, 1966
- Stereochemical Relationship Between Coding Triplets and Amino-AcidsNature, 1966