Thermodynamic Description of Liquid-Solid Chromatography Process in the Optimization of Separation Conditions of Organic Compound Mixture

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Abstract
Continuous interest in chromatographic methods as analitical techniques of different compounds separation gives rise to studies on theoretical description of chromatographic systems and, at the same way, to the selection of the best way of the prediction of chromatographic separation results. The main problem of theoretical studies in adsorption chromatography is to describe precisely correlations between retention parameters of given solute and mobile phase composition. In present paper the effort was made to use thermodynamic description of adsorbent - binary solvent - substance systems for theoretical predictions of analytical separation results in high-performance liquid column and thin-layer chromatography. The attention was paid to the possibility of using thin-layer chtomatography as a method of an initial choice of chtomatographic process optimization.