α‐Methyldopa For Climacteric Hot Flushes: A Double‐Blind, Randomized, Cross‐Over Study

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Abstract
The effects of single evening doses of α‐methyldopa and placebo have been compared in 40 women with climacteric hot flushes. the study was designed as a double‐blind, randomized and cross‐over investigation. of the 24 patients who completed the study, 15 reported that they preferred the α‐methyldopa treatment (p<0.05). α‐methyl‐dopa seemed to affect both the severity (p0.05). It is concluded that α‐methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.

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