Histamine and Human Heart
- 1 January 1985
- journal article
- mast cells
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 77 (1-2) , 174-176
- https://doi.org/10.1159/000233777
Abstract
Heart fragments obtained from human right atrium contain 1.5 ± 0.2 μg of histamine per gram of wet tissue. Human heart spontaneously synthetizes significant amounts of PGI2, PGF2α, PGE2 and TxA2. The Ca2+ ionophore A 23187 (0.5–3 μg/ml) dose-dependently induces histamine release and prostanoid production. Histamine (0.5–1 μg/kg/min) infusion in 10 normal donors produced an increase in heart rate and a significant depression of the ST segment. Selective H1 receptor stimulation in patients undergoing cardiac catheterization resulted in a decrease of the mean aortic pressure and of coronary vascular resistance.Keywords
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