Energy Boost: The Warburg Effect Returns in a New Theory of Cancer
Top Cited Papers
Open Access
- 14 December 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 96 (24) , 1805-1806
- https://doi.org/10.1093/jnci/96.24.1805
Abstract
In 1930, German biochemist Otto Warburg, M.D., proposed that cancer was caused by altered metabolism—deranged energy processing—in the cell. Warburg, winner of a Nobel Prize in 1931, is now considered by many to be the greatest biochemist of the first half of the 20th century. His cancer theory, though, mostly fell on deaf ears. Altered metabolism “may be a symptom of [cancer], but not the primary cause,” wrote fellow biochemist and Nobelist Hans Krebs, M.D., Ph.D., echoing the majority viewpoint. Warburg went to his grave in 1970 insisting he was right, but for 30 years his cancer theory appeared to be buried along with its originator.Keywords
This publication has 1 reference indexed in Scilit:
- Why do cancers have high aerobic glycolysis?Nature Reviews Cancer, 2004