Male Sterility Associated with Familial Translocation Heterozygosity: t(8;15) (q22;p11)

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Abstract
During the investigation of the family of a subject consulting for primary sterility, the same oligoteratospermia was found in 2 of his brothers. The 3 karyotypes of these subjects exhibited an equilibrated reciprocal autosomal translocation t(8;15) (q22;p11) also detected in their mother. The karyotypes of the remaining siblings, 1 brother and 1 sister, were normal. The semen analysis of the sterile subjects suggests that the block of gamete production occurs at the beginning of spermiogenesis. The chromosomal anomaly, which has no effect on the reproduction of the mother, leads to sterility of the male offspring bearing it.