Risk factors forNeisseria meningitidescarriage in a school during a community outbreak of meningococcal infection

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Abstract
As part of the management of an outbreak of meningococcal infection, 119 school contacts of an index case were swabbed for nasopharyngeal carriage. In a cohort study, risk factors forNeisseria meningitidiscarriage were ascertained by means of a questionnaire, completed by 114 (96%) of those swabbed.Twenty five (21%) cultures were identified as ‘neisseria positive’; of which there were 18 (15%)Neisseria meningitidisisolates, 2 (2%)Neisseria lactamicaisolates and 5 (4%) showed contaminants only. Two (2%) carriers were identified as harbouring the implicated outbreak strain. Single variable analysis identified six statistically significant risk factors for meningococcal carriage; increasing age, female sex, manual social class, personal smoking, regular attendance at a discotheque and rhinorrhoea. Multivariate analysis, using logistic regression modelling, found that of these six variables only age, sex and social class remained statistically significant when the other factors were controlled for. Nevertheless the role of smoking, social events and respiratory/viral infections in nasopharyngeal carriage, and other plausible mechanisms whereby age, sex and social class might exert their effect, could usefully be investigated further.