EFFECT OF CALCIUM GLUCONATE INFUSION ON RENIN IN DOG

Google Scholar
  • 1 January 1977
    • journal article
    • research article
    • Vol. 89  (1) , 181-189
Abstract
Infusion of CaCl2 into the renal artery of the dog inhibits renin release. To evaluate the possible importance of the anion delivered with Ca, similar experiments were performed in 10 dogs with equivalent amounts of calcium gluconate (0.3 mg of Ca++/kg body weight per min). The experiment consisted of 3 successive 15 min control periods, followed by three 15 min calcium gluconate infusion periods and two 15 min recovery periods. During calcium gluconate infusion, mean serum Ca++, and ECa++, ENa+ and EFNa+ from the infused kidney increased (P < 0.005). Systolic blood pressure (142 mm Hg .+-. 8 SE), renal blood flow (137 ml/min .+-. 11 SE), creatinine clearance and aldosterone excretion (12.0 ng/15 min .+-. 1.5 SE) did not change (P > 0.3). Renal venous PRA (28.4 ng/ml per h .+-. 7.5 SE) decreased (P < 0.014). The per cent decrease of PRA correlated (r = -0.70) with the per cent increase EFNa+ (P < 0.001). Calcium gluconate had a lesser (P < 0.01) inhibitory effect on renin than CaCl2, despite greater excretion of Ca++ and Na+ during calcium gluconate infusion. Taken together, the results indicate that Ca++ inhibits renin release, although the extent of the inhibition is modified by the anion accompanying Ca++. The effect of Ca++ on renin may be mediated by NaCl transport across the macula densa.

This publication has 2 references indexed in Scilit: