DISSOCIATION OF RESULTS OBTAINED WITH AN IMMUNOFLUORESCENCE TECHNIQUE BY USING ANTI-ACTH ANTIBODIES IN 3 CASES OF PITUITARY CHROMOPHOBE ADENOMA WITHOUT HYPERCORTICISM - ULTRASTRUCTURAL STUDY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 37  (1) , 55-56
Abstract
Morphological studies of 3 pituitary chromophobe adenomas in patients without hypercorticism showed positive immunofluorescent cells with anti-.alpha., 17-39 ACTH antibody which were not revealed with anti-.beta., 1-24 ACTH antibody. These cells observed at the ultrastructural level contained secretory granules 1000-1500 .ANG. in diameter. The existence in these cells of a substance having an immunological relationship with ACTH without biological activity is discussed.

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