Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil
- 1 December 1989
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 264 (2) , 617-620
- https://doi.org/10.1042/bj2640617
Abstract
Neutrophils stimulated with formylmethionyl-leucylphenylalanine (fMet-Leu-Phe) in the presence of butanol and ethanol formed phosphatidyl alcohols through a phospholipase D mechanism. The alcohols inhibited phosphatidic acid and diradylglycerol (DRG) formation, but did not block inositol 1, 4, 5-trisphosphate release. fMet-Leu-Phe-stimulated superoxide production was inhibited by alcohol concentrations which blocked DRG formation, whereas opsonized-zymosan-stimulated superoxide production was only partially decreased. These results suggest that phospholipase D activation is functionally linked to superoxide production in the human neutrophil.This publication has 33 references indexed in Scilit:
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