HEXAMETHYLMELAMINE IN OVARIAN-CANCER RESISTANT TO CYCLOPHOSPHAMIDE AND ADRIAMYCIN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 63  (8) , 1375-1377
Abstract
Patients (34) resistant to cyclophosphamide and adriamycin received hexamethylmelamine at 1 of 2 dose regimens: 6 mg/kg per day orally for 21 days every 4 wk or 8 mg/kg per day orally for 21 days every 6 wk. Only 5 patients responded. Tolerance to the drug was, however, satisfactory; nausea, pyrosis and vomiting were the only frequent side effects. Myelosuppression occurred in only 1 case.