Thiamin deprivation in ventromedial hypothalamic hyperphagic rats: Anorexia, specificity of food aversion, and a dietary consideration.
- 1 February 1979
- journal article
- research article
- Published by American Psychological Association (APA) in Journal of Comparative and Physiological Psychology
- Vol. 93 (1) , 140-150
- https://doi.org/10.1037/h0077585
Abstract
The anorexic consequence of thiamine deprivation was investigated in ventromedial hypothalamic (VMH) hyperphagic rats under either high-fat or low-fat thiamine free diet conditions. The low-fat diet maintained feeding significantly longer in thiamine-deprived VMH rats than in intact rats, whereas the high-fat diet sustained feeding in thiamine deficient intact rats and accelerated anorexia onset in vitamin B1 deprived VMH rats. This effect was noted under both ad lib and pair-feeding conditions. Thiamine-deprived VMH rats subjected to weight control developed anorexia sooner than intact subjects regardless of the diet employed. The VMH rats fed a high-fat diet failed to resume feeding after thiamine administration, which was interpreted as a permanent aversion to this diet. The relation between dietary intake and conditioned taste aversion was discussed with reference to the VMH and intact rat.Keywords
This publication has 0 references indexed in Scilit: