Induction of Xenobiotic Metabolism in Rat Liver by Chlorinated Biphenyl Ether Isomers
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 3 (3) , 293-303
- https://doi.org/10.3109/01480548009002224
Abstract
Chlorinated diphenyl ether isomers were administered to rats at doses of 10 µmols/kg/day po for 3 days. Decachlorodiphenyl ether caused increases in EPN detoxification, NADPH cytochrome c reductase and cytochrome P-450 but did not alter aryl hydrocarbon hydroxylase (AHH). It caused a shift in P450 absorption to 448 nm. 2,4,5,2',4'-Pentachlorodiphenyl ether increased EPN detoxification and cytochrome P-450. 2,4,5,3',4'-Pentachlorodiphenyl ether increased AHH and cytochrome P-450 and caused a shift in the absorption maximum to 448 nm. 3,4,2',4'-Tetrachlorodiphenyl ether induced AHH. 2,4'-Dichlorodiphenyl ether, 4,4'-dichlorodiphenyl ether, 2,4,2'-trichlorodiphenyl ether, 2,4,4'-trichlorodiphenyl ether, 3,4,2'-trichlorodiphenyl ether and 3,4,2',4'-tetrachlorodiphenyl ether did not alter any of these parameters. The position and degree of chlorination are important in determining the extent of induction and pathways induced.This publication has 18 references indexed in Scilit:
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