A STUDY OF THE DISTRIBUTION AND FATE OF ANTIMONY WHEN USED AS TARTAR EMETIC AND FUADIN IN THE TREATMENT OF AMERICAN SOLDIERS WITH SCHISTOSOMIASIS JAPONICA

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Abstract
The Rhodamine B method of Maren for the detn. of Sb has been modified in order to make it more sensitive and specific. The blank due to Fe has been eliminated by precipitating ferric ferrocyanide directly in the reaction mixture. When 0.5-5 [mu]g. quantities of Sb were added to 5-ml. portions of plasma, urine, and blood and to 0.5 g. of feces, they were recovered with an ayg. error of less than 5%. One hundred thirty-eight patients were given 156 courses of treatment consisting of the admn. on alternate days of tartar emetic or of fuadin equivalent to 45 mg. of Sb. After 0.75 g. of Sb had been given in approx. 5 wks. the avg. plasma Sb cone, in both groups was about 100 [mu]g./ L. Four wks. later, the conc, was 20 [mu]g./L. From 15 min.-4 hrs. after drug admn., the fuadin values were considerably greater than those of the tartar emetic group. At all stages of treatment with both drugs, the Sb cone, in the blood cells was definitely greater than that of plasma. For several hrs. after drug admn. the tartar emetic group had decidedly higher blood cell cones, than did the fuadin group. The combined excretion in urine and feces toward the end of treatment was roughly 24 mg. in 2 days or about 55% of the amt. administered in the preceding dose. Small amts. were still being excreted more than 100 days later. Ninety-two patients were followed by serial stool examination for an avg. of 3 mos. after completion of treatment. Within this period 82% of 33 patients treated with fuadin were again passing eggs, whereas only 19% of 59 patients treated with tartar emetic were again passing eggs.

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