Effects of Androgens on Proliferation and Progesterone Receptor Levels in T47D Human Breast Cancer Cells

1 January 1993

journal article
Published by Springer Nature in Tumor Biology

Vol. 14 (1) , 38-45
https://doi.org/10.1159/000217823

Abstract

The effects of estradiol (E₂), dihydrotestosterone (DHT) and dehydro-3-epiandrosterone (DHEA) on proliferation and progesterone receptor induction were studied in a breast cancer cell line (T47D) expressing estrogen, androgen, and progesterone receptors. A significant enhancement of growth and progesterone receptor expression was observed after treatment with E₂ and DHEA, which was antagonized by the anties-trogen tamoxifen and not altered by the antiandrogen flutamide, supporting the involvement of estrogen receptors. When cells were treated with either E₂ or DHEA, transforming growth factor-α mRNA was induced. DHT treatment did not alter growth but was effective in stimulating androgen receptors and down-regulating progesterone receptors.

Keywords

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