ANTIGEN PRESENTATION BY EPITHELIAL-CELLS OF THE RAT SMALL-INTESTINE .1. KINETICS, ANTIGEN-SPECIFICITY AND BLOCKING BY ANTI-IA ANTISERA
- 1 May 1986
- journal article
- research article
- Vol. 58 (1) , 1-7
Abstract
Columnar epithelial cells (EC), isolated from the proximal small intestine of the rat, bind ovalbumin (OVA) by a non-specific, cold-inhibitable mechanism and continue to express Ia antigens after 24 hr culture in vitro. Lymph node T cells from rats immunized with OVA proliferate following 18 hr coculture with EC and OVA. This accessory cell function of EC is antigen-specific and is blocked by anti-Ia monoclonal antisera.This publication has 28 references indexed in Scilit:
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