Influence of Dietary Fat on Incidence of Alloxan Diabetes in Growing Rats
- 31 March 1955
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 181 (1) , 183-186
- https://doi.org/10.1152/ajplegacy.1955.181.1.183
Abstract
Young rats fed adequate rations containing 10 or 20% fat were rendered diabetic by 1 or 2 subcutaneous injections of 200 mg alloxan/kg body weight. The diabetogenic and toxic action of the drug was influenced by the nature of the dietary fat, as judged from diabetic incidence and mortality rate: butter fat afforded more protection as compared with peanut oil. Apparently, the favorable influence of butter fat is related to a greater content of saturated fatty acids. In alloxan diabetic animals the urinary excretion of riboflavin was markedly increased.Keywords
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