A receptor for green tea polyphenol EGCG
Top Cited Papers
- 14 March 2004
- journal article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (4) , 380-381
- https://doi.org/10.1038/nsmb743
Abstract
The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value.Keywords
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