Toxicological approaches to streptothricin antibiotics. II. The developmental mechanism of delayed toxicity in mice and rats.

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Abstract
In order to investigate the mode of the delayed toxicity of streptothricin antibiotics, 14C-glycyl-racemomycin-A and racemomycin-D were each administered i.v. to mice and rats. As to the distribution of 14C-glycyl-racemomycin-A in the organs of mice, studies confirmed us that it was distributed in kidney in high concentration in comparison with the distribution in the other organs. Pathohistological reviews were carried out on the kidney which was whitened macroscopically. Severe toxicity wide-spread in the cortex renis was observed in the kidney. Streptothricin antibiotics evidently produce nephrotoxicity. As to the developmental mechanism of the delayed toxicity, after the antibiotic is administered in vivo it is transformed into acid, the lactam ring is broken [determined by radiochromatogram examination of the metabolite in urine] and the acute toxicity of that acid is a apparently responsible for the delayed toxicity.

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