18F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization
Open Access
- 16 October 2009
- journal article
- review article
- Published by Society of Nuclear Medicine in Journal of Nuclear Medicine
- Vol. 50 (11) , 1820-1827
- https://doi.org/10.2967/jnumed.108.054098
Abstract
It is hoped that in the not too distant future, noninvasive imaging–based molecular interrogation and characterization of tumors can improve our fundamental understanding of the dynamic biologic behavior of cancer. For example, the new dimension of diagnostic information that is provided by 18F-FDG PET has led to improved clinical decision making and management changes in a substantial number of patients with cancer. In this context, the aim of this review is to bring together and summarize the current data on the correlation between the underlying molecular biology and the clinical observations of tumor 18F-FDG accumulation in 3 major human cancers: lung, breast, and colon.Keywords
This publication has 103 references indexed in Scilit:
- Warburg revisited: imaging tumour blood flow and metabolismCancer Imaging, 2008
- The maximum uptake of 18F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1α and GLUT-1 in non-small cell lung cancerEuropean Journal Of Cancer, 2007
- FDG uptake and glucose transporter type 1 expression in lymph nodes of non-small cell lung cancerEuropean Journal of Surgical Oncology, 2006
- Correlation of GLUT-1 Overexpression, Tumor Size, and Depth of Invasion with 18F-2-fluoro-2-deoxy-d-glucose Uptake by Positron Emission Tomography in Colorectal CancerDigestive Diseases and Sciences, 2006
- Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondriaOncogene, 2006
- Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor-1α and its significanceJournal of Hepatology, 2004
- Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological featuresEuropean Journal Of Cancer, 2001
- General Auditory Processes Contribute to Perceptual Accommodation of CoarticulationPhonetica, 2000
- The Hallmarks of CancerCell, 2000
- FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor modelsNuclear Medicine and Biology, 1994