Mitigating Mutational Meltdown in Mammalian Mitochondria
Open Access
- 19 February 2008
- journal article
- primer
- Published by Public Library of Science (PLoS) in PLoS Biology
- Vol. 6 (2) , e35
- https://doi.org/10.1371/journal.pbio.0060035
Abstract
Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.Keywords
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