Interrelationship of free fatty acids and glucose metabolism in the dog

Publisher Website
Google Scholar
Abstract
1-C14-labeled palmitic acid or glucose-C14(U) was infused iv at constant rate in unanesthetized dogs with indwelling arterial and venous catheters. O2 uptake, CO2 output, rates of turnover, and oxidation of plasma FFA or of plasma glucose were measured. There was an inverse correlation between RQ and plasma FFA level and between RQ and percent CO2 derived from FFA, a positive correlation between RQ and contribution of plasma glucose to exhaled CO2. Infusions of Na-nicotinate decreased the turnover rate and oxidation of plasma FFA in both normal and pancreatectomized dogs; increased the RQ and rates of turnover and oxidation of plasma glucose in normal dogs only; and in diabetic dogs reduced the hepatic glucose output. In normal dogs the plasma FFA level showed an inverse correlation with the turnover rate of glucose and with percent CO2 derived from glucose. It was concluded that, in normal dogs, the plasma level of FFA influences the participation of carbohydrate in energy metabolism; in diabetic dogs the high FFA level seems to increase hepatic glucose output.