The Effect of Adrenaline on the Hexosephosphate Content of Vascular Smooth Muscle

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Abstract
In experiments on isolated vascular smooth muscle adrenaline at a concentration of 10–3caused a 2‐to 3‐fold increase in the content of glucose‐6‐phosphate, fructose‐6‐phosphate, fructose‐1–6‐diphosphate and dihydroxyacetone phosphate during isometric contraction 7 min after addition of the drug. This action of adrenaline was manifest both under aerobic and under anaerobic conditions, and in the presence as well as in the absence of glucose. Fructose‐1–6‐diphosphate showed a relatively greater increase than fructose‐6‐phosphate. — Since in previous experiments on vascular muscle no glycogeno‐lytic effect of adrenaline had been detectable, the possibility that hexosephosphates was formed from some other carbohydrate metabolite is discussed.