SOS-Independent Induction ofdinBTranscription by β-Lactam-Mediated Inhibition of Cell Wall Synthesis inEscherichia coli
Open Access
- 15 February 2005
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (4) , 1515-1518
- https://doi.org/10.1128/jb.187.4.1515-1518.2005
Abstract
Transcription of the dinB gene, encoding DNA polymerase IV, is induced by the inhibition of cell wall synthesis at different levels. Using the β-lactam antibiotic ceftazidime, a PBP3 inhibitor, as a model, we have shown that this induction is independent of the LexA/RecA regulatory system. Induction of dinB transcription mediated by ceftazidime produces an increase in the reversion of a +1 Lac frameshift mutation.Keywords
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