Synthesis of nucleoside di- and tri-phosphates via nucleoside 5′-phosphoric di-n-butylphosphinothioic anhydride intermediates
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 196-197
- https://doi.org/10.1039/c39750000196
Abstract
Reaction of di-n-butylphosphinothioyl bromide with nucleotides afforded almost quantitatively the corresponding nucleoside phosphoric di-n-butylphosphinothioic anhydrides, which are quite stable even in the presence of water; in the presence of AgOAc they react readily with inorganic phosphate or pyrophosphate to give the corresponding nucleoside di- or tri-phosphates respectively.Keywords
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