The protection of primates against soman poisoning by pretreatment with pyridostigmine
- 1 September 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 31 (1) , 295-299
- https://doi.org/10.1111/j.2042-7158.1979.tb13504.x
Abstract
The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 μg kg−1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. Theprotection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.This publication has 8 references indexed in Scilit:
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