EFFECTS OF INTRA-VENTRICULARLY ADMINISTERED GABA AND PICROTOXIN AND THEIR INTERACTIONS ON SOMATE-VEGETATIVE REFLEXES IN CATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 231  (1) , 139-147
Abstract
The effects of intraventricularly (3rd, 4th and lateral cerebral ventricles) applied GABA and picrotoxin on blood pressure and reflexogenic hypertension and nictitating membrane contractions after central sciatic nerve stimulation were studied in lightly anesthetized cats. The interactions between both substances were also studied. Picrotoxin caused a strong elevation of blood pressure and a long lasting contraction of the nictitating membrane when infused into each part of the cerebral ventricular system. These effects of picrotoxin were antagonized by GABA. GABA inhibited the reflexogenic hypertension when given into the 4th ventricle and the reflexogenic nictitating membrane contractions given into the 3rd and 4th ventricles. Picrotoxin antagonized the inhibitory effects of GABA on the reflexogenic nictitating membrane contractions. In the central regulation of some somato-vegetative reflexes the GABA-ergic transmitter system takes part.

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