Comparison of the bronchodilator and vasodilator activity of sodium azide and sodium nitroprusside in the guinea-pig
- 1 October 1979
- journal article
- research article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 6 (5) , 515-525
- https://doi.org/10.1111/j.1440-1681.1979.tb00034.x
Abstract
1. Sodium azide and sodium nitroprusside are potent dilators of the intact guinea-pig tracheal preparation in vitro. 2. Both substances are bronchodilators in the anaesthetized guinea-pig in vivo when administered intravenously or by aerosol inhalation. 3. Sodium azide and sodium nitroprusside are also potent vasodilators in the guinea pig. 4. At all doses and by route of administration, including aerosol inhalation, the hypotensive effect predominates over bronchodilatation.Keywords
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