Impaired Parasite Growth and Increased Susceptibility to Phagocytosis of Plasmodium falciparum Infected Alpha-Thalassemia or Hemoglobin Constant Spring Red Blood Cells
- 1 April 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 89 (4) , 521-525
- https://doi.org/10.1093/ajcp/89.4.521
Abstract
In vitro multiplication of Plasmodium falciparum in hemoglobin H or hemoglobin Constant Spring red blood cells (from homozygotes or double heterozygotes) was significantly reduced as compared with that in normal erythrocytes. The parasitized genetically abnormal red blood cells showed further-more a high propensity for being phagocytosed by peripheral blood monocytes. Both impaired parasite growth and increased susceptibility to phagocytosis may be related to mechanisms for protection of the variants from P. falciparum infection.This publication has 1 reference indexed in Scilit:
- Phagocytosis of Nucleated and Mature β Thalassaemic Red Blood Cells by Mouse Macro-phages in VitroBritish Journal of Haematology, 1979